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Re-Glyco

ctrl+K

or

A GlycoProtein Builder

1

Choose Structure

AF, PDB or upload your own

2

Select Glycans

Choose your N- or O-glycan

3

Download

Press process and download re-glyco structure!

About

Re-Glyco is a tool we designed to restore the missing glycosylation on glycoproteins deposited in the RCSB PDB or in the EBI-EMBL AlphaFold protein structure database. To get started, upload your protein structure file or choose a pre-existing AlphaFold or PDB structure, and let Re-Glyco do the rest! Below are some example of UniProt IDs to get you started:

and press fetch!

Currently supported function includes :
N-GlcNAcylation
O-GalNAcylation
O-GlcNAcylation
O-Fucosylation
O-Mannosylation
O-Glucosylation
O-Xylosylation
C-Mannosylation
O-Arabinosylation

Licence and Attribution

All of the data provided is freely available for academic use under Creative Commons Attribution 4.0 (CC BY-NC-ND 4.0 Deed) licence terms. Please contact us at elisa.fadda@soton.ac.uk for Commercial licence. If you use this resource, please cite the following papers:

Ives, C.M., Singh, O. et al. Restoring protein glycosylation with GlycoShape. Nat Methods (2024).

The structures provided in this resource are generated with in-silico standards and should be interpreted carefully.